Background & Aims
Abbreviations:ALT (alanine aminotransferase), AST (aspartate aminotransferase), BMI (body mass index), ELISA (enzyme-linked immunosorbent assay), GDM (gestational diabetes mellitus), GGT (gamma-glutamyl transferase), HDL (high-density lipoprotein), HOMA-IR (homeostasis model assessment-insulin resistance), hs-CRP (high-sensitivity C-reactive protein), LGA (large-for-gestational age), MAFLD (metabolic dysfunction-associated fatty liver disease), MD (metabolic dysfunction), NAFLD (non-alcoholic fatty liver disease), SGA (small-for-gestational age), T2DM (type 2 diabetes mellitus), TG (triglyceride), WC (waist circumference)
Publication stageIn Press Journal Pre-Proof
S.M.L, W.K. and J.S.P designed the research; S.M.L, Y.M.J., E.S.C., J.N.K., I.H.O., B.J.K., S.M.K., S.Y.K., G.M.K., S.K.J., S.S., W.K. and J.S.P conducted the research; S.M.L., S.H.K., B.K.K., E.R.N., C.W.P., and J.K.J analyzed the data; S.M.L, W.K. and J.S.P wrote the manuscript, and S.M.L, Y.M.J., E.S.C., S.H.K., J.N.K., I.H.O., B.J.K., S.M.K., S.Y.K., G.M.K., S.K.J., B.K.K., S.S., E.R.N., C.W.P., J.K.J, W.K. and J.S.P revised the manuscript; W.K. and J.S.P had access to all data and had primary responsibility for the final content.
Grant support: This work was supported by the Seoul National University Hospital research fund (0320212200), a National Research Foundation of Korea grant funded by the Korea government (MEST) (2021R1A2C2005820, 2021M3A9E4021818).
Conflict of interest: None to declare for all authors.
WHAT YOU NEED TO KNOW
Background: Recently, metabolic dysfunction-associated fatty liver disease (MAFLD), rather than nonalcoholic fatty liver disease (NAFLD), was proposed to better describe liver disease associated with metabolic dysfunction (MD). However, there have been some debates regarding this renaming, since the clinical impact of this change has not been fully evaluated.
Findings: The risk of subsequent development of adverse pregnancy outcomes was higher in women with MAFLD than in non-MD NAFLD women, whereas the risk was not significantly different between women without NAFLD and women with non-MD NAFLD.
Implications for patient care: To predict adverse pregnancy outcomes as early as possible, the presence of MAFLD should be evaluated in pregnant women in the first trimester, and further validation studies are warranted to incorporate this hypothesis into current practice guidelines for pregnant women at high risk for adverse pregnancy outcomes.