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Pernicious Anemia, Atrophic Gastritis, and the Risk of Cancer

      Close to one-fourth of all human cancers arise in the gastrointestinal tract. These cancers are associated with significant burden and high mortality. Gastric cancer has the highest incidence and mortality rates worldwide.
      • Colquhoun A.
      • Arnold M.
      • Ferlay J.
      • et al.
      Global patterns of cardia and non-cardia gastric cancer incidence in 2012.
      Global 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.
      Its annual incidence approximates 950,000 cases; the annual mortality is 840,000.
      • Colquhoun A.
      • Arnold M.
      • Ferlay J.
      • et al.
      Global patterns of cardia and non-cardia gastric cancer incidence in 2012.
      Global 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.
      This reflects a persisting overall fatality rate close to 90%.
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      Linked Article

      • Cancer Risk After Pernicious Anemia in the US Elderly Population
        Clinical Gastroenterology and HepatologyVol. 13Issue 13
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          Pernicious anemia, a result of autoimmune gastritis, is the most common cause of vitamin B12 deficiency, affecting 2% to 5% of the elderly population. Treatment with vitamin B12 cures the anemia, but not the gastritis. Findings from small studies have indicated that patients with pernicious anemia could have an increased risk of cancer.
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