Management of Dyslipidemia as a Cardiovascular Risk Factor in Individuals With Nonalcoholic Fatty Liver Disease

  • Kathleen E. Corey
    Affiliations
    Department of Medicine, Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts
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  • Naga Chalasani
    Correspondence
    Reprint requests Address requests for reprints to: Naga Chalasani, MD, Professor of Medicine and Cellular and Integrative Physiology, Chief, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4100, Indianapolis, Indiana 46202; fax: (317) 278-1949.
    Affiliations
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
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Published:August 19, 2013DOI:https://doi.org/10.1016/j.cgh.2013.08.014
      Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of liver disease in the United States and is associated with an increased risk of cardiovascular disease (CVD) and cardiovascular (CV) mortality, independent of traditional cardiovascular risk factors. CVD is one of the most common causes of death among individuals with NAFLD and management of NAFLD must extend beyond liver disease to include CVD risk modification. Clinicians should assess CVD risk with the Framingham Risk Score and screen for CVD risk factors including dyslipidemia, diabetes mellitus, hypertension, tobacco use, and the metabolic syndrome. CVD risk factors, particularly dyslipidemia, require aggressive medical management to reduce the high risk of CVD events and death in individuals with NAFLD.

      Keywords

      Abbreviations used in this paper:

      CV (cardiovascular), CVD (cardiovascular disease), DM (diabetes mellitus), FRS (Framingham Risk Score), HDL (high-density lipoprotein), HDL-C (HDL-cholesterol), LDL (low-density lipoprotein), MetS (metabolic syndrome), NAFLD (nonalcoholic fatty liver disease), NASH (nonalcoholic steatohepatitis), NCEP (National Cholesterol Education Program), OSA (obstructive sleep apnea)
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