Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma

Published:February 14, 2011DOI:https://doi.org/10.1016/j.cgh.2011.01.023

      Background & Aims

      Nonalcoholic steatohepatitis (NASH) can progress to hepatocellular carcinoma (HCC). We aimed to characterize the clinical features of NASH patients with HCC.

      Methods

      In a cross-sectional multicenter study in Japan, we examined 87 patients (median age, 72 years; 62% male) with histologically proven NASH who developed HCC. The clinical data were collected at the time HCC was diagnosed.

      Results

      Obesity (body mass index ≥25 kg/m2), diabetes, dyslipidemia, and hypertension were present in 54 (62%), 51 (59%), 24 (28%), and 47 (55%) patients, respectively. In nontumor liver tissues, the degree of fibrosis was stage 1 in 10 patients (11%), stage 2 in 15 (17%), stage 3 in 18 (21%), and stage 4 (ie, liver cirrhosis) in 44 (51%). The prevalence of cirrhosis was significantly lower among male patients (21 of 54, 39%) compared with female patients (23 of 33, 70%) (P = .008).

      Conclusions

      Most patients with NASH who develop HCC are men; the patients have high rates of obesity, diabetes, and hypertension. Male patients appear to develop HCC at a less advanced stage of liver fibrosis than female patients.

      Keywords

      Abbreviations used in this paper:

      AFP (α-fetoprotein), ALT (alanine aminotransferase), AST (aspartate aminotransferase), BMI (body mass index), CT (computed tomography), DCP (des-γ-carboxy prothrombin), γ-GTP (γ-glutamyl transpeptidase), HCC (hepatocellular carcinoma), HDL (high-density lipoprotein), MRI (magnetic resonance imaging), NAFLD (nonalcoholic fatty liver disease), NASH (nonalcoholic steatohepatitis)
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