A Systematic Review of the Efficacy of Domperidone for the Treatment of Diabetic Gastroparesis

  • Aravind Sugumar
    Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
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  • Amanpal Singh
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas
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  • Pankaj Jay Pasricha
    Address requests for reprints to: Pankaj J. Pasricha, MD, Professor of Medicine, Chief, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building, Room M211, Stanford, California 94305-5187. fax: (650) 723-5488.
    Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California
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      Background & Aims: Despite being widely used in more than 20 countries for the treatment of diabetic gastroparesis for several decades, domperidone is approved only on an investigational basis in the United States. However, because its use is increasing, it is important for gastroenterologists in this country to understand its effectiveness in this condition. The literature on this subject varies considerably with respect to the methods and outcome measures, making a meta-analysis unfeasible. Methods: Our objective was to systematically analyze studies of the efficacy of domperidone in diabetic gastroparesis, with a focus on their methodologic and scientific merit. Information from 28 trials (11 full articles and 17 abstracts) from 1981 to 2007 was analyzed. Results: The average study quality score was 8.3 out of a possible 15 and the total sample size equaled 1016. Overall, 64% of the studies showed significant efficacy of domperidone on the improvement of symptoms. Sixty percent of the studies showed an efficacy in gastric emptying and 67% of the studies proved the drug effective in reducing hospital admissions. Conclusions: Overall, our assessment is that there is level 3 evidence for the efficacy of domperidone in diabetic gastroparesis, leading to a grade C recommendation for its use in this condition. These results need to be interpreted very cautiously because of significant methodologic limitations of these studies, including the fact that most positive studies lacked a control arm. It is clear that larger and better-designed studies are needed to further validate the use of this drug in diabetic gastroparesis.

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