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Cover
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Miscellaneous
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page OFC
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| Electronic Images of the Month |
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Article Title |
Author(s) |
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Pyogenic Liver Abscess Spontaneously Drained Into the Stomach
25 May 2009
A 46-year-old Caucasian man presented with septic fever (intermittent, with spikes up to 40.5°C) and intense abdominal pain in the upper quadrants. He had drunk 2 infusions of unspecified herbs of unc...
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Eugenio Caturelli,
Paola Roselli,
Giorgia Ghittoni
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Short communication
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page e65
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Endoscopic Resection of an Ileal Inflammatory Fibroid Polyp Using Retrograde Single-Balloon Enteroscopy
14 July 2009
A 73-year-old woman was referred to our tertiary care center for evaluation of occult gastrointestinal bleeding. After an unrevealing esophagogastroduodenoscopy and colonoscopy, wireless capsule endos...
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Jordan H. Wolff,
William S. Twaddell,
Peter E. Darwin
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Short communication
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pages e66-e67
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Pseudomelanosis Duodeni: An Unusual Finding From Upper Gastrointestinal Endoscopy
10 August 2009
A 54-year-old man underwent upper gastrointestinal endoscopy during a physical exam. Significant features of his medical history included 10 years of hypertension that had been controlled with hydrala...
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Hsu–Heng Yen,
Yang–Yuan Chen,
Maw–Soan Soon
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Short communication
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page e68
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Unusual Lesions of the Liver
10 August 2009
A 57-year-old man was referred to our hospital because of lesions of the liver discovered as an accidental finding on a magnetic resonance imaging (MRI) of the heart. The MRI was performed because of ...
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Sita V. Jansen,
Roy F.A. Vliegen,
C. Minke Bakker
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Short communication
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page e69
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| CME Activities |
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Exam 1: Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring Recommendations
27 September 2009
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C. Mel Wilcox
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Examination
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pages 1141-1142
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Exam 2: Fewer Polyps Detected by Colonoscopy as the Day Progresses at a Veteran's Administration Teaching Hospital
27 September 2009
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C. Mel Wilcox
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Examination
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page 1143
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| Abstracts From Around the World |
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Abstracts from Around the World
12 October 2009
Recent attention has focused on the potential deleterious effects of radiation exposure from medical imaging procedures. Experimental and epidemiologic evidence suggests that low dose exposure to ioni...
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Discussion
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pages 1144-1146
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| Editorials |
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Endoscopic Ulcers Are Neither Meaningful Nor Validated as a Surrogate for Clinically Significant Upper Gastrointestinal Harm
26 June 2009
“A correlate does not a surrogate make.”
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David Y. Graham
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Editorial
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pages 1147-1150
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Chronic Diarrhea Due to Excessive Bile Acid Synthesis and Not Defective Ileal Transport: A New Syndrome of Defective Fibroblast Growth Factor 19 Release
10 August 2009
Elsewhere in this issue Julian Walters and his colleagues report a major advance in our understanding of the pathogenesis of chronic diarrhea associated with idiopathic bile acid malabsorption. The st...
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Alan F. Hofmann,
David J. Mangelsdorf,
Steven A. Kliewer
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Editorial
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pages 1151-1154
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Yes, Simultaneous Damage to Both the Pancreas and Liver Are Associated in Subjects Who Drink Excessive Amounts of Alcohol!
09 September 2009
It has generally been accepted that although excessive alcohol intake might lead to liver damage or pancreatic damage, both conditions are rarely associated, and the pathogenesis of the tissue injury ...
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Phillip P. Toskes
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Editorial
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page 1155
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| Review |
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Evidence for Endoscopic Ulcers as Meaningful Surrogate Endpoint for Clinically Significant Upper Gastrointestinal Harm
13 April 2009
Background & Aims: Surrogate endpoints are biomarkers intended to substitute for a clinical endpoint. Are endoscopic ulcers a useful surrogate endpoint for a biological progression to clinical end...
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Andrew Moore,
Ingvar Bjarnason,
Byron Cryer,
Luis Garcia–Rodriguez,
Larry Goldkind,
Angel Lanas,
Lee Simon
et al.
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Review article
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pages 1156-1163
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| Education Practice |
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Author(s) |
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A 38-Year-Old With Recurrent Colitis. Is It Noncompliance?
03 July 2009
A 38-year-old man with a 5 year history of ulcerative colitis presents for follow-up. He was diagnosed at age 33 when he presented with diarrhea, bleeding, urgency cramps, and weight loss. He was trea...
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Sunanda Kane
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Full-length article
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pages 1164-1167
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| Perspective |
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United States Health Care Reform in 2009: A Primer for Gastroenterologists
23 July 2009
The US health care system is characterized by staggering costs alongside limited access, uneven quality, and subpar health outcomes. Although federal policymakers have long acknowledged this health ca...
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Spencer D. Dorn
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Full-length article
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pages 1168-1173
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| Endoscopy Corner |
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Author(s) |
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Does Stent Placement for Advanced Colon Cancer Increase the Risk of Perforation During Bevacizumab-Based Therapy?
23 July 2009
Background & Aims: Data on the safety of bevacizumab-based therapies for patients carrying a self-expandable metallic stent (SEMS) for occlusive colon cancer are lacking. We report 2 cases of colo...
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Vincenzo Cennamo,
Lorenzo Fuccio,
Vita Mutri,
Maria Eugenia Minardi,
Leonardo Henry Eusebi,
Liza Ceroni,
Liboria Laterza,
Luca Ansaloni,
Antonio Daniele Pinna,
Nunzio Salfi,
Andrea Angelo Martoni,
Franco Bazzoli
et al.
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Full-length article
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pages 1174-1176
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Complications Associated With Double Balloon Enteroscopy at Nine US Centers
14 July 2009
Background & Aims: Double balloon enteroscopy (DBE) was introduced into the US in 2004. Potential complications include perforation, pancreatitis, and gastrointestinal bleeding. Prevalence and ris...
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Lauren B. Gerson,
Jeffrey Tokar,
Michael Chiorean,
Simon Lo,
G. Anton Decker,
David Cave,
Doumit BouHaidar,
Daniel Mishkin,
Charles Dye,
Oleh Haluszka,
Jonathan A. Leighton,
Alvin Zfass,
Carol Semrad
et al.
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Full-length article
 
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pages 1177-1182.e3
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| Original Articles-Alimentary Tract |
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Article Title |
Author(s) |
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Optimized Protocol for Diagnosis of Acute Ileitis
23 July 2009
Background & Aims: Suspected acute ileitis (AI) is a poorly defined clinical condition with multiple causes; its diagnostic protocol has not been standardized properly. We performed a prospective ...
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Elena Garrido,
Antonio L. Sanromán,
Miguel A. Rodríguez–Gandía,
Miguel Rivero,
Ana Royuela,
Víctor Moreira,
José María Milicua
et al.
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Full-length article
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pages 1183-1188
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A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis
08 May 2009
Background & Aims: Primary (idiopathic) bile acid malabsorption (BAM) is a common, yet underrecognized, chronic diarrheal syndrome. Diagnosis is difficult without selenium homocholic acid taurine ...
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Julian R.F. Walters,
Ali M. Tasleem,
Omer S. Omer,
W. Gordon Brydon,
Tracy Dew,
Carel W. le Roux
et al.
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Full-length article

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pages 1189-1194
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Timing of Myelosuppression During Thiopurine Therapy for Inflammatory Bowel Disease: Implications for Monitoring Recommendations
23 July 2009
Background & Aims: Thiopurines (azathioprine and 6-mercaptopurine) can induce life-threatening myelosuppression. This study determined the frequency, timing, and outcomes of mild and severe myelos...
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James D. Lewis,
Oren Abramson,
Monina Pascua,
Liyan Liu,
Laura M. Asakura,
Fernando S. Velayos,
Susan M. Hutfless,
James E. Alison,
Lisa J. Herrinton
et al.
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Full-length article
 
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pages 1195-1201
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The Probiotic Preparation, VSL#3 Induces Remission in Patients With Mild-to-Moderately Active Ulcerative Colitis
23 July 2009
Background & Aims: Probiotics can maintain ulcerative colitis (UC) in remission effectively, but little is known of their ability to induce remission. We conducted a multicenter, randomized, doubl...
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Ajit Sood,
Vandana Midha,
Govind K. Makharia,
Vineet Ahuja,
Dinesh Singal,
Pooja Goswami,
Rakesh K. Tandon
et al.
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Full-length article
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pages 1202-1209.e1
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An Association Between Microscopic Colitis and Celiac Disease
23 July 2009
Background & Aims: Microscopic colitis has been associated with celiac disease. We aimed to determine the extent and significance of this relationship. Methods: A prospectively maintained database...
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Peter H.R. Green,
Jun Yang,
Jianfeng Cheng,
Anne R. Lee,
Jason W. Harper,
Govind Bhagat
et al.
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Full-length article
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pages 1210-1216
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Fewer Polyps Detected by Colonoscopy as the Day Progresses at a Veteran's Administration Teaching Hospital
23 July 2009
Background & Aims: One objective of colonoscopy is to identify and remove polyps—this process requires attention to detail and prolonged concentration. Providers are predisposed to cognitive error...
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Michael Y. Chan,
Hartley Cohen,
Brennan M.R. Spiegel
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Full-length article
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pages 1217-1223
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| Original Articles-Liver, Pancreas, and Biliary Tract |
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Article Title |
Author(s) |
Type |
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Independent Predictors of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
26 June 2009
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. We investigated factors associated with advanced fibrosis in NAFLD. Methods: The study inclu...
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Noreen Hossain,
Arian Afendy,
Maria Stepanova,
Fatema Nader,
Manirath Srishord,
Nila Rafiq,
Zachary Goodman,
Zobair Younossi
et al.
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Full-length article
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pages 1224-1229.e2
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Levels and Initial Course of Serum Alanine Aminotransferase Can Predict Outcome of Patients With Budd–Chiari Syndrome
29 June 2009
Background & Aims: Patients with Budd–Chiari syndrome can present with acute, subacute, or chronic disease; the definitions and significance of these variants have been disputed. An increased leve...
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Pierre–Emmanuel Rautou,
Rami Moucari,
Dominique Cazals–Hatem,
Sylvie Escolano,
Cécile Denié,
Ludivine Douarin,
Claire Francoz,
François Durand,
Violaine Ozenne,
Audrey Imbert,
Richard Moreau,
Didier Lebrec,
Aurélie Plessier,
Dominique Valla
et al.
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Full-length article
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pages 1230-1235
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New Model for End Stage Liver Disease Improves Prognostic Capability After Transjugular Intrahepatic Portosystemic Shunt
29 June 2009
Background & Aims: Cirrhotic patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) for refractory ascites or recurrent variceal bleeding are at risk for decompensation and death...
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Jennifer Guy,
Ma Somsouk,
Stephen Shiboski,
Robert Kerlan,
John M. Inadomi,
Scott W. Biggins
et al.
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Full-length article
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pages 1236-1240
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Pancreas and Liver Injury Are Associated in Individuals With Increased Alcohol Consumption
29 June 2009
Background & Aims: Although chronic pancreatitis and liver cirrhosis are common sequelae of excess alcohol consumption, the 2 conditions are rarely associated. We studied the prevalence of simulta...
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Andrea Pace,
Andreas de Weerth,
Marc Berna,
Katharina Hillbricht,
Michael Tsokos,
Michael Bläker,
Klaus Pueschel,
Ansgar W. Lohse
et al.
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Full-length article
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pages 1241-1246
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Early Systemic Inflammatory Response Syndrome Is Associated With Severe Acute Pancreatitis
17 August 2009
Background & Aims: There have been few clinical studies of systemic inflammatory response syndrome (SIRS) in patients with acute pancreatitis. The aim of this study was to evaluate the role of SIR...
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Vikesh K. Singh,
Bechien U. Wu,
Thomas L. Bollen,
Kathryn Repas,
Rie Maurer,
Koenraad J. Mortele,
Peter A. Banks
et al.
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Full-length article
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pages 1247-1251
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| Brief Communication |
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Article Title |
Author(s) |
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Do We Know What Patients Want? The Doctor-Patient Communication Gap in Functional Gastrointestinal Disorders
03 July 2009
Background & Aims: Understanding patients' expectations at initial consultation for functional gastrointestinal disorders (FGIDs) might influence future health care utilization. Ideally, patients ...
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Joanne Collins,
Edwina Farrall,
Deborah A. Turnbull,
David J. Hetzel,
Gerald Holtmann,
Jane M. Andrews
et al.
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Short communication
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pages 1252-1254.e2
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| Letters to the Editor |
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Author(s) |
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Colorectal Cancer Risk Reduction After Polypectomy: Evidence Against the National Polyp Study
04 June 2009
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Cesare Hassan,
Angelo Zullo
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Correspondence
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page 1255
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Reply
23 September 2009
We thank Drs Hassan and Zullo for their interest in our article. To our knowledge, there are no large cohort studies of long-term follow-up after screening colonoscopy to which our results can be dire...
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Charles J. Kahi,
Thomas F. Imperiale,
Beth E. Juliar,
Douglas K. Rex
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Correspondence
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pages 1255-1256
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Reply
23 September 2009
The following reply refers to a letter to the editor (Reiss G, Ramrakhiani S. Right upper-quadrant pain and a normal abdominal ultrasound. Clin Gastroenterol Hepatol 2009;7:603) published in the May 2...
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Furqaan Ahmed,
Evan Fogel
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Correspondence
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page 1256
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Reply
23 September 2009
The following reply refers to a letter to the editor (de Vries HE, Van Oijen MGH, de Jong DJ. Safety of infliximab in inflammatory bowel disease needs to be debated. Clin Gastroenterol Hepatol 2009;7:...
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Sarah Caspersen,
Christian Mortensen,
Lene Riis,
Tine Jess,
Flemming Bendtsen
et al.
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Correspondence
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page 1257
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| Frontmatter |
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Editorial Board
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Editorial board
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page A4
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Contents
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Contents list
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pages A9-A12
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Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute br...
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Miscellaneous
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pages A15-A16
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Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship
In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for ot...
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Miscellaneous
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page A17
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| Images of the Month |
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Article Title |
Author(s) |
Type |
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Chronic Diarrhea, Weight Loss, and Refractory Epilepsy Three Years After Percutaneous Endoscopic Gastrostomy
27 February 2009
A 46-year-old man presented to our hospital with a 2-month history of chronic diarrhea and weight loss. Moreover, his long-standing epilepsy had become refractory to therapy even with a combination of...
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Franziska Piccoli–Gfeller,
Christoph Beglinger,
Michael Manz
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Short communication
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page A18
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Peutz–Jeghers Syndrome: A Rare Cause of Gastric Outlet Obstruction
02 February 2009
A 16-year-old female patient with notable mucocutaneous pigmentation and a history of recurrent small bowel intussusception presented with a gastric outlet obstruction. A computed tomography scan reve...
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Shannon Chang,
John Kalarickal,
Virendra Joshi
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Short communication
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page A20
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Aortoenteric Fistula: An Uncommon Cause of Hematemesis With Characteristic Clinical Presentation
08 October 2009
A 77-year-old woman presented to the emergency department with hematemesis. A previous esophagogastroduodenoscopy (EGD) for anemia was reported as negative. Her medical history was significant for isc...
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Ivan Jovanovic,
Irena Mojsic,
Tomica Milosavljevic
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Short communication
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page A22
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Meckel's Diverticulum Diagnosed by Double-Balloon Enteroscopy in an Adult Presenting With Obscure Gastrointestinal Bleeding
12 March 2009
A 31-year-old man presented to our hospital because of a 2-month history of intermittent hematochezia. He had a history of a peptic ulcer 3 years previously. Physical examination was unremarkable othe...
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Jen–Wei Chou
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Short communication
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page A24
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Double-Balloon Enteroscopy for the Diagnosis of Meckel's Diverticulum in a 50-Year-Old Man With Obscure Gastrointestinal Bleeding
02 April 2009
A 50-year-old man presented to an outside facility with a 5-day history of intermittent hematochezia. This was associated with symptoms of fatigue, dyspnea on exertion, and headache. Blood work reveal...
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Mouen Khashab,
Michael V. Chiorean
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Short communication
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page A26
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