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Cover
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Miscellaneous
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page OFC
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Inflammation and Carcinogenesis in the Pancreas and Biliary Tract: Mechanisms and Practice
Among the diseases treated by gastroenterologists, those involving the pancreas and the biliary tract are often the most challenging. However, recent advances in our knowledge of disease mechanisms, n...
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Tooru Shimosegawa,
Fred S. Gorelick
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Editorial
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pages S1-S2
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Recent Developments in Acute Pancreatitis
The incidence of acute pancreatitis (AP) has been increasing worldwide, but the major etiologies remain gallstones and alcohol. Several studies have reported that smoking is an independent risk factor...
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Rupjyoti Talukdar,
Santhi Swaroop Vege
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Full-length article
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pages S3-S9
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The Acinar Cell and Early Pancreatitis Responses
Pathologic responses arising from the pancreatic acinar cell appear to have a central role in initiating acute pancreatitis. Environmental factors that sensitize the acinar cell to harmful stimuli lik...
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Fred S. Gorelick,
Edwin Thrower
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Full-length article
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pages S10-S14
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Long-Term Prognosis of Acute Pancreatitis in Japan
This study was undertaken to evaluate the long-term prognosis of acute pancreatitis (AP) in Japan and to identify factors that predict major complications. In 1987, 2533 patients with moderate or seve...
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Yoshifumi Takeyama
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Full-length article
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pages S15-S17
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Long-Term Follow-Up of Autoimmune Pancreatitis: Characteristics of Chronic Disease and Recurrence
Autoimmune pancreatitis is a unique disease, characterized by lymphoplasmacytic inflammation in the acute stages. However, the active clinical features are unlikely to persist for long periods. Throug...
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Shigeyuki Kawa,
Hideaki Hamano,
Yayoi Ozaki,
Tetsuya Ito,
Ryou Kodama,
Yoshimi Chou,
Mari Takayama,
Norikazu Arakura
et al.
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Full-length article
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pages S18-S22
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Chronic Pancreatitis and Pancreatic Cancer: Prediction and Mechanism
We investigated the SPINK 1 mutations in 156 sporadic pancreatic cancer (PCa), and 8 pancreatic cancer with chronic pancreatitis (CPPCa) patients, and in 527 healthy subjects. The results demonstrated...
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Tooru Shimosegawa,
Kiyoshi Kume,
Kennichi Satoh
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Full-length article
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pages S23-S28
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Germ-Line Mutations, Pancreatic Inflammation, and Pancreatic Cancer
The fundamental problem underlying pancreatic cancer is altered genetics. Rare germ-line mutations lead to familial cancer syndromes that may include pancreatic cancer. But why do some people develop ...
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David Whitcomb,
Julia Greer
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Full-length article
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pages S29-S34
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Molecular Pathology of Pancreatic Cancer: Implications for Molecular Targeting Therapy
Pancreatic cancer develops through ductal dysplastic lesions or pancreatic intraepithelial neoplasia (PanIN). The origin of pancreatic cancer remains controversial. Some of the molecular origins of pa...
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Toru Furukawa
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Full-length article
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pages S35-S39
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Ras Activity in Acinar Cells Links Chronic Pancreatitis and Pancreatic Cancer
The relationship between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) is unclear. CP is a risk factor for PDAC, CP is found within the vicinity of PDAC, and both share many si...
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Craig D. Logsdon,
Baoan Ji
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Full-length article
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pages S40-S43
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Desmoplasia of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is characterized by remarkable desmoplasia. The desmoplasia is composed of extracellular matrix (ECM) proteins,...
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Stephen Pandol,
Mouad Edderkaoui,
Ilya Gukovsky,
Aurelia Lugea,
Anna Gukovskaya
et al.
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Full-length article
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pages S44-S47
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Roles of Pancreatic Stellate Cells in Pancreatic Inflammation and Fibrosis
Over a decade, there is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic fibrosis. In response to pancreatic injury or inflamm...
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Atsushi Masamune,
Takashi Watanabe,
Kazuhiro Kikuta,
Tooru Shimosegawa
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Full-length article
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pages S48-S54
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Differentiating Neoplastic From Benign Lesions of the Pancreas: Translational Techniques
There has been substantial recent progress in our ability to image and sample the pancreas leading to the improved recognition of benign and premalignant conditions of the pancreas such as autoimmune ...
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Asif Khalid
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Full-length article
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pages S55-S58
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Distinguishing Pancreatic Cancer From Autoimmune Pancreatitis: A Comparison of Two Strategies
Autoimmune pancreatitis is a rare disease which closely mimics pancreatic cancer in its presentation. It is important for clinicians to distinguish one from the other due to vastly different therapeut...
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Aravind Sugumar,
Suresh T. Chari
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Full-length article
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pages S59-S62
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Diagnosis of Pancreatic Disorders Using Contrast-Enhanced Endoscopic Ultrasonography and Endoscopic Elastography
Contrast-enhanced endoscopic ultrasonography (CE-EUS) and EUS-elastography are cutting-edge diagnostic modalities for pancreatic disorders. Each pancreatic disorder has characteristic hemodynamics. CE...
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Yoshiki Hirooka,
Akihiro Itoh,
Hiroki Kawashima,
Eizaburo Ohno,
Takuya Ishikawa,
Hiroshi Matsubara,
Yuya Itoh,
Masanao Nakamura,
Ryoji Miyahara,
Naoki Ohmiya,
Yasumasa Niwa,
Masatoshi Ishigami,
Yoshiaki Katano,
Hidemi Goto
et al.
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Full-length article
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pages S63-S67
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Intrahepatic Cholangiocarcinoma Progression: Prognostic Factors and Basic Mechanisms
In this review, we will examine various molecular biomarkers for their potential to serve as independent prognostic factors for predicting survival outcome in postoperative patients with progressive i...
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Alphonse E. Sirica,
Catherine I. Dumur,
Deanna J.W. Campbell,
Jorge A. Almenara,
Olorunseun O. Ogunwobi,
Jennifer L. Dewitt
et al.
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Full-length article
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pages S68-S78
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Differential Diagnosis and Treatment of Biliary Strictures
Biliary tract strictures present both diagnostic and therapeutic challenges to clinicians. Advances in imaging and endoscopic techniques have improved our ability to differentiate between benign and m...
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Kazuo Inui,
Junji Yoshino,
Hironao Miyoshi
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Full-length article
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pages S79-S83
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Pancreaticobiliary Maljunction
Pancreaticobiliary maljunction (PBM) is a congenital anomaly defined as a junction of the pancreatic and bile ducts located outside the duodenal wall, usually forming a markedly long common channel. I...
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Terumi Kamisawa,
Kensuke Takuma,
Hajime Anjiki,
Naoto Egawa,
Masanao Kurata,
Goro Honda,
Kouji Tsuruta,
Tsuneo Sasaki
et al.
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Full-length article
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pages S84-S88
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Inflammation and Carcinogenesis of the Biliary Tract: Update On Endoscopic Treatment
Both diagnosis and treatment of cholangiocarcinoma are suboptimal. From the former standpoint, fluorescence in situ hybridization, direct cholangioscopy, endocystoscopy, and optical coherence tomograp...
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Richard A. Kozarek
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Full-length article
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pages S89-S94
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| Frontmatter |
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Editorial Board
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Editorial board
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page A1
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Contents
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Contents list
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pages A3-A4
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Disclaimer Page
“Inflammation and Carcinogenesis in the Pancreas and Biliary Tract: Mechanism and Practice”
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Miscellaneous
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page A5
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Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute br...
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Miscellaneous
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pages A6-A7
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Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship
In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for ot...
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Miscellaneous
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page A8
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