| Electronic Image of the Month |
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T1 Pancreatic Cancer With Lymph Node Metastasis and Perineural Invasion of the Celiac Trunk
11 August 2008
A 76-year-old man with a single episode of diarrhea displayed an increased CA 19-9 value on routine laboratory examinations. The patient did not complain of pain, jaundice, weight loss, diabetes melli...
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Carolin Reiser–Erkan,
Jochen Gaa,
Jörg Kleeff
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Short communication
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pages e41-e42
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| CME Activities |
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Exam 1: Infliximab for Inflammatory Bowel Disease in Denmark 1999–2005: Clinical Outcome and Follow-Up Evaluation of Malignancy and Mortality
15 October 2008
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Michael B. Fallon
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Examination
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pages 1175-1176
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Exam 2: Progression to Colorectal Neoplasia in Ulcerative Colitis: Effect of Mesalamine
13 October 2008
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Michael B. Fallon
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Examination
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page 1177
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| Abstracts From Around the World |
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Abstracts from Around the World
17 October 2008
Pech O, Behrens A, May A, et al. Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with a high-grade intraepithelial neoplasia and mucosal ade...
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Discussion
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pages 1178-1179
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| Editorials |
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Surgery or Ablation Therapy for HGD in Patients With Barrett's Esophagus?
13 October 2008
Patients with Barrett's esophagus and high-grade dysplasia are likely to either harbor co-existent carcinoma or are certainly more likely to progress to esophageal adenocarcinoma over time. Thus, the ...
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Mohamad A. Eloubeidi
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Editorial
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page 1180
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Selecting Treatment for Barrett's Esophagus: No Second Chances to Make a First Impression
01 September 2008
The treatment of Barrett's esophagus with high-grade dysplasia or early cancer remains controversial in the minds of physicians. Clearly, there are biases that are based on the perspective of the back...
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Kenneth K. Wang
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Editorial
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pages 1181-1182
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Where the Twains Should Meet
04 August 2008
The article by Yachimski et al aimed to identify predictors of treatment for patients with Barrett's esophagus (BE) and high-grade dysplasia (HGD) or intramucosal carcinoma (IMC). The interesting find...
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Carolyn E. Reed
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Editorial
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pages 1183-1184
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| Review |
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The Effect of Hospital and Surgeon Volume on Outcomes for Rectal Cancer Surgery
02 October 2008
Despite many studies of rectal cancer outcomes, no clear relationship between hospital or surgeon volume and patient outcomes has emerged for rectal cancer. We aimed to characterize the effect of hosp...
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Talya Salz,
Robert S. Sandler
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Review article
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pages 1185-1193
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| Clinical Imaging |
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Update in Imaging of Cystic Pancreatic Masses for Gastroenterologists
16 September 2008
Cystic pancreatic masses are increasingly recognized as a direct consequence of widespread imaging. Once detected, there is controversy as to further management. This review briefly describes the radi...
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Alec J. Megibow
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Full-length article
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pages 1194-1197
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| Education Practice |
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Right Upper Quadrant Pain and a Normal Abdominal Ultrasound
A 30-year-old woman is referred for evaluation of a 1-year history of intermittent, debilitating, postprandial right upper quadrant pain associated with nausea and occasional vomiting. The pain can la...
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Furqaan Ahmed,
Evan L. Fogel
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Full-length article
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pages 1198-1201
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| Endoscopy Corner |
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Usefulness of Double-Balloon Endoscopy in the Diagnosis of Malignant Small-Bowel Tumors
18 September 2008
Background & Aims: Double-balloon endoscopy (DBE) enables endoscopic and histopathologic diagnosis of malignant small-bowel tumors (MSBT). This study examined the clinical features of patients wit...
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Hirokazu Yamagami,
Nobuhide Oshitani,
Shuhei Hosomi,
Takehisa Suekane,
Noriko Kamata,
Mitsue Sogawa,
Hirotoshi Okazaki,
Kenji Watanabe,
Kazunari Tominaga,
Toshio Watanabe,
Yasuhiro Fujiwara,
Tetsuo Arakawa
et al.
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Full-length article
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pages 1202-1205
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| Original Articles-Alimentary Tract |
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Treatment of Barrett's Esophagus With High-Grade Dysplasia or Cancer: Predictors of Surgical Versus Endoscopic Therapy
11 July 2008
Background & Aims: Patients with Barrett's esophagus and high-grade dysplasia or intramucosal carcinoma are at risk of progression to invasive carcinoma. Both esophagectomy and endoscopic ablation...
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Patrick Yachimski,
Norman S. Nishioka,
Ethan Richards,
Chin Hur
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Full-length article
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pages 1206-1211
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Infliximab for Inflammatory Bowel Disease in Denmark 1999–2005: Clinical Outcome and Follow-Up Evaluation of Malignancy and Mortality
10 October 2008
Background & Aims: Data on safety and long-term follow-up evaluation of population-based cohorts of inflammatory bowel disease (IBD) patients treated with infliximab are sparse. The aim of this ar...
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Sarah Caspersen,
Margarita Elkjaer,
Lene Riis,
Natalia Pedersen,
Christian Mortensen,
Tine Jess,
Pernille Sarto,
Tanja S. Hansen,
Vibeke Wewer,
Flemming Bendtsen,
Flemming Moesgaard,
Pia Munkholm,
Danish Crohn Colitis Database
et al.
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Full-length article
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pages 1212-1217
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Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn's Disease
18 September 2008
Background & Aims: The quantitative relationships between instruments and assays that measure clinical, endoscopic, and biologic disease activity in patients with Crohn's disease are poorly charac...
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Jennifer Jones,
Edward V. Loftus,
Remo Panaccione,
Li–Sheng Chen,
Sandra Peterson,
Joseph Mcconnell,
Linnea Baudhuin,
Karen Hanson,
Brian G. Feagan,
Scott W. Harmsen,
Alan R. Zinsmeister,
Emelie Helou,
William J. Sandborn
et al.
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Full-length article
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pages 1218-1224
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Progression to Colorectal Neoplasia in Ulcerative Colitis: Effect of Mesalamine
10 October 2008
Background & Aims: Some studies have suggested that mesalamine can prevent the development of colorectal cancer in patients with ulcerative colitis (UC). The aim of this study was to compare rates...
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Thomas Ullman,
Victoria Croog,
Noam Harpaz,
Sabera Hossain,
Asher Kornbluth,
Carol Bodian,
Steven Itzkowitz
et al.
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Full-length article
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pages 1225-1230
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Cost Effectiveness of Colonoscopy, Based on the Appropriateness of an Indication
Background & Aims: Determination of the appropriateness of an indication for colonoscopy has been advanced as a means to help rationalize the use of endoscopic resources. However, the efficacy and...
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Cesare Hassan,
Emilio Di Giulio,
Perry J. Pickhardt,
Angelo Zullo,
Andrea Laghi,
David H. Kim,
Franco Iafrate,
Sergio Morini
et al.
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Full-length article
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pages 1231-1236
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Risk of Developing Adenomas and Carcinomas in the Ileal Pouch in Patients With Familial Adenomatous Polyposis
13 October 2008
Background & Aims: At present, more than half of patients with familial adenomatous polyposis (FAP) are treated with a proctocolectomy and an ileal pouch–anal anastomosis (IPAA). Originally it was...
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Pieter Friederich,
Andrea E. de Jong,
Lisbeth M. Mathus–Vliegen,
Eveline Dekker,
Han H. Krieken,
Jan Dees,
Fokko M. Nagengast,
Hans F.A. Vasen
et al.
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Full-length article
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pages 1237-1242
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| Original Articles-Liver, Pancreas, and Biliary Tract |
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Placebo in Nonalcoholic Steatohepatitis: Insight Into Natural History and Implications for Future Clinical Trials
28 July 2008
Background & Aims: Changes in biochemical and histologic parameters related to nonalcoholic steatohepatitis (NASH) in placebo-treated patients may provide an insight into the natural history and h...
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Rohit Loomba,
Robert Wesley,
Frank Pucino,
T. Jake Liang,
David E. Kleiner,
Joel E. Lavine
et al.
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Full-length article
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pages 1243-1248
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Cytokeratin 18 Fragment Levels as a Noninvasive Biomarker for Nonalcoholic Steatohepatitis in Bariatric Surgery Patients
28 July 2008
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is extremely common among morbidly obese patients. We assessed the usefulness of plasma caspase–generated cytokeratin 18 (CK-18) fragmen...
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Dima L. Diab,
Lisa Yerian,
Philip Schauer,
Sangeeta R. Kashyap,
Rocio Lopez,
Stanley L. Hazen,
Ariel E. Feldstein
et al.
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Full-length article
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pages 1249-1254
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Elevated Soluble Tumor Necrosis Factor Receptor 75 Concentrations Identify Patients With Liver Cirrhosis at Risk of Death
Background & Aims: Elevated levels of the soluble 75-kd receptor for tumor necrosis factor–alpha (sTNF-R 75) are better predictors of mortality in cirrhosis than the Child-Turcotte-Pugh (CTP) scor...
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Frank Grünhage,
Bettina Rezori,
Markus Neef,
Frank Lammert,
Tilman Sauerbruch,
Ulrich Spengler,
Christoph Reichel
et al.
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Full-length article
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pages 1255-1262
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Reproducibility of Liver Stiffness Measurement by Ultrasonographic Elastometry
01 September 2008
Background & Aims: Fibroscan is a noninvasive device that assesses liver fibrosis by liver stiffness evaluation (LSE) with ultrasonographic elastometry. We evaluated LSE reproducibility and its in...
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Jérôme Boursier,
Anselme Konaté,
Gabriella Gorea,
Stéphane Reaud,
Emmanuel Quemener,
Frédéric Oberti,
Isabelle Hubert–Fouchard,
Nina Dib,
Paul Calès
et al.
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Full-length article
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pages 1263-1269
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DNA Methylation Alterations In Endoscopic Retrograde Cholangiopancreatography Brush Samples of Patients With Suspected Pancreaticobiliary Disease
09 September 2008
Background & Aims: Molecular markers of pancreatic neoplasia could aid in the evaluation of suspicious pancreatic lesions where cytology is nondiagnostic. We evaluated the utility of detecting and...
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Mansour A. Parsi,
Ang Li,
Chung–Pin Li,
Michael Goggins
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Full-length article
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pages 1270-1278
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| Brief Communication |
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Small Bowel Injury by Low-Dose Enteric-Coated Aspirin and Treatment With Misoprostol: A Pilot Study
Background & Aims: With capsule endoscopy, the ulcerogenic effect of low-dose enteric-coated aspirin on the small bowel and the therapeutic effect of misoprostol on intestinal injury were evaluate...
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Toshio Watanabe,
Satoshi Sugimori,
Natsuhiko Kameda,
Hirohisa Machida,
Hirotoshi Okazaki,
Tetsuya Tanigawa,
Kenji Watanabe,
Kazunari Tominaga,
Yasuhiro Fujiwara,
Nobuhide Oshitani,
Kazuhide Higuchi,
Tetsuo Arakawa
et al.
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Full-length article
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pages 1279-1282
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| Letters to the Editor |
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Clinical, Pathologic, and Molecular Characterization of Familial Eosinophilic Esophagitis Compared With Sporadic Cases
11 August 2008
In their comparison of familial and sporadic eosinophilic esophagitis, Collins et al list as an inclusion criterion a threshold peak count of 24 or more eosinophils per high-power field in an esophage...
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Henry Appelman
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Correspondence
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page 1283
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Reply
17 October 2008
Dr Appelman inquires about our use of an inclusion criterion of ≥24 eosinophils/high power field (hpf) in our comparison of familial and eosinophilic esophagitis in view of a consensus statement publi...
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Margaret H. Collins,
Phil E. Putnam,
Marc E. Rothenberg
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Correspondence
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page 1283
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Cover
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Miscellaneous
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page OFC
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| Frontmatter |
| Images of the Month |
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Hepatic Ultrasound Appearance and Colonoscopic Finding of Schistosomiasis japonica
01 July 2008
A 78-year-old man presented with abdominal bloating and constipation. Laboratory studies revealed no abnormality. Colonoscopy revealed an 8 × 8 mm lesion elevated with a central depression and small u...
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Akira Horiuchi,
Yoshiko Nakayama,
Kenji Sano
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Short communication
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page A24
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Glycogenic Hepatopathy: A Rare Cause of Increased Aminotransferase Levels in a Diabetic Patient
08 August 2008
A 19-year-old woman with type 1 diabetes mellitus presented with an 18-month history of increased aminotransferase levels and poorly controlled diabetes (HgbA1C 10.1%). She took glargine and lispro in...
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John T. Bassett,
Ganesh R. Veerappan,
Dong H. Lee
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Short communication
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page A26
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A Rare Anatomic Variant: 2 Anatomically Distinct Major Duodenal Papillae
08 August 2008
A 54-year-old man with a history of inflammatory bowel disease and abnormal liver-associated enzyme levels presented for an endoscopic retrograde cholangiopancreatography for the evaluation of possibl...
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Mansour A. Parsi
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Short communication
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page A28
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Mosaic-Patterned and Scalloped Duodenal Mucosa in Whipple's Disease
08 August 2008
A 67-year-old woman was admitted to the hospital for evaluation of a 2-year history of a 30-kg unintentional weight loss, fatigue, arthralgia, nonbloody diarrhea, and iron-deficiency anemia. She denie...
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Franco Armelao,
Federica Portolan,
Roberto Togni
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Short communication
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page A32
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Information for Readers
Correspondence regarding subscriptions or change of address should be directed to Clinical Gastroenterology and Hepatology, Elsevier, Periodicals Department, 6277 Sea Harbor Dr, Orlando, FL 32887-4800...
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Miscellaneous
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page A2
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Editorial Board
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Editorial board
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page A4
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Contents
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Contents list
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pages A9-A12
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Online Access Information
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Miscellaneous
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page A12
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Information for Authors
Clinical Gastroenterology and Hepatology publishes original papers, review articles, brief communications, and special category articles on all aspects of the digestive tract and the liver. Manuscript...
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Miscellaneous
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pages A17-A20
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Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship
In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for ot...
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Miscellaneous
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page A22
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