| Electronic Images of the Month |
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Hepatic Artery Compression of the Common Hepatic Duct: Direct Visualization by Single-Operator Peroral Cholangioscopy
02 December 2011
A 54-year-old man presented with right upper-quadrant abdominal pain, jaundice, and pruritis. His initial total bilirubin level was 5.8 mg/dL, aspartate aminotransferase level was 186 U/L, alanine ami...
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Daniel Eshtiaghpour,
Viktor E. Eysselein,
Sofiya Reicher
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e45
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Solitary Liver Mass in a Patient With Hepatitis C
26 December 2011
A 64-year-old man with a history of intravenous drug use and chronic hepatitis C virus (HCV) presented with shortness of breath, 1 month of severe right upper quadrant abdominal pain, and a 10-pound w...
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Nora E. Renthal,
Judy Peih Ying Tsai,
Dennis K. Burns
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e46
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| CME Activities |
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Exam 1: Identification of Cholangiocarcinoma by Using the Spyglass Spyscope System for Peroral Cholangioscopy and Biopsy Collection
19 March 2012
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Shyam S. Varadarajulu
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e47-e48
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Exam 2: A Predictive Model Identifies Patients Most Likely to Have Inadequate Bowel Preparation for Colonoscopy
19 March 2012
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Shyam S. Varadarajulu
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e49
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| Abstracts From Around the World |
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Abstracts from Around the World
19 March 2012
While we appreciate that the risk of progression to carcinoma is infrequent in patients with nondysplastic Barrett's esophagus (BE), it is unclear if there are any lifestyle factors that may enhance t...
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443-446
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| Editorials |
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Predicting Outcomes After Restorative Proctocolectomy for Ulcerative Colitis
30 January 2012
An estimated 1 million Americans have ulcerative colitis (UC) and Crohn's disease (CD). The majority of CD patients will require at least one surgery during the course of their disease, and 30%–40% of...
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Konstantinos A. Papadakis
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447-449
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Safety of Cardiac Surgery in Cirrhotic Patients: Going to the Heart of the Matter
30 January 2012
Liver cirrhosis is associated with several cardiac alterations that include both diastolic and systolic dysfunction and electrical abnormalities such as QT prolongation. Impaired myocardial contractil...
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Edoardo G. Giannini
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450-451
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| Review |
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An Algorithm for Risk Assessment and Intervention of Mother to Child Transmission of Hepatitis B Virus
10 November 2011
Background & Aims: Despite immunoprophylaxis, mother to child transmission (MTCT) of hepatitis B virus (HBV) still occurs in infants born to hepatitis B surface antigen (HBsAg)–positive mothers. W...
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Calvin Q. Pan,
Zhong–Ping Duan,
Kalyan R. Bhamidimarri,
Huai–Bin Zou,
Xiao–Feng Liang,
Jie Li,
Myron J. Tong
et al.
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452-459
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| Education Practice |
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Initiating Azathioprine for Crohn's Disease
13 February 2012
Azathioprine (AZA) and 6-mercaptopurine are therapeutic options for patients with moderate to severe inflammatory Crohn's disease. AZA has both a complex metabolism and potential for adverse events th...
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Barrett G. Levesque,
Edward V. Loftus
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460-465
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| Endoscopy Corner |
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Identification of Cholangiocarcinoma by Using the Spyglass Spyscope System for Peroral Cholangioscopy and Biopsy Collection
19 December 2011
Background & Aims: It is a challenge to collect samples from bile duct strictures to diagnose patients with cholangiocarcinoma. We investigated the utility of the Spyglass Spyscope, a single-opera...
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Ali A. Siddiqui,
Vaibhav Mehendiratta,
Whitney Jackson,
David E. Loren,
Thomas E. Kowalski,
Mohamad A. Eloubeidi
et al.
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466-471
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| Practice Management: Opportunities and Challenges |
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Can the Humanities Mend Medicine?
Dr Howard Spiro passed away on March 11, 2012. He was the founding chief of the Gastroenterology Section at Yale, a position he held from 1955–1982. During that time, he became widely known for his cl...
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Howard Spiro
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472-474
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| Original Articles—Alimentary Tract |
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Erosive Reflux Disease Increases Risk for Esophageal Adenocarcinoma, Compared With Nonerosive Reflux
16 January 2012
Background & Aims: Gastroesophageal reflux disease is a strong risk factor for esophageal adenocarcinoma, but it is not clear whether the mucosal inflammation that develops in patients with reflux...
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Rune Erichsen,
Douglas Robertson,
Dora K. Farkas,
Lars Pedersen,
Heiko Pohl,
John A. Baron,
Henrik T. Sørensen
et al.
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475-480.e1
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Esophageal Diameter Is Decreased in Some Patients With Eosinophilic Esophagitis and Might Increase With Topical Corticosteroid Therapy
10 February 2012
Background & Aims: The rapid response to topical corticosteroids makes it hard to implicate fibrosis as the cause of dysphagia in patients with eosinophilic esophagitis (EoE). We examined surrogat...
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Joohee Lee,
James Huprich,
Christine Kujath,
Karthik Ravi,
Felicity Enders,
Thomas C. Smyrk,
David A. Katzka,
Nicholas J. Talley,
Jeffrey A. Alexander
et al.
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481-486
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Helicobacter pylori Infection Is Strongly Associated With Gastric and Duodenal Ulcers in a Large Prospective Study
10 January 2012
Background & aims: Infection with Helicobacter pylori (H pylori) is a risk factor for peptic ulcer disease (PUD), but there are limited longitudinal data on the associations between infection and ...
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Ben Schöttker,
Mariam A. Adamu,
Melanie N. Weck,
Hermann Brenner
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487-493.e1
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Factors Associated With Persistent and Nonpersistent Chronic Constipation, Over 20 Years
30 January 2012
Background & Aims: The prevalence of chronic constipation (CC) has been reported to be as high as 20% in the general population, but little is known about its natural history. We estimated the nat...
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Rok Seon Choung,
G. Richard Locke,
Enrique Rey,
Cathy D. Schleck,
Charles Baum,
Alan R. Zinsmeister,
Nicholas J. Talley
et al.
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494-500
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A Predictive Model Identifies Patients Most Likely to Have Inadequate Bowel Preparation for Colonoscopy
11 January 2012
Background & Aims: An inadequate level of bowel preparation can affect the efficacy and safety of colonoscopy. Although some factors have been associated with outcome, there is no strategy to iden...
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Cesare Hassan,
Lorenzo Fuccio,
Mario Bruno,
Nico Pagano,
Cristiano Spada,
Silvia Carrara,
Chiara Giordanino,
Emanuele Rondonotti,
Gabriele Curcio,
Pietro Dulbecco,
Carlo Fabbri,
Domenico Della Casa,
Stefania Maiero,
Adriana Simone,
Federico Iacopini,
Giuseppe Feliciangeli,
Gianpiero Manes,
Antonio Rinaldi,
Angelo Zullo,
Francesca Rogai,
Alessandro Repici
et al.
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501-506
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Antimicrobial Antibodies Are Associated With a Crohn's Disease–Like Phenotype After Ileal Pouch–Anal Anastomosis
03 October 2011
Background & Aims: Pouchitis and Crohn's disease (CD)-like (CDL) complications of the pouch occur at rates near 50% and 20%, respectively, after colectomy with ileal pouch–anal anastomosis (IPAA) ...
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Andrea D. Tyler,
Raquel Milgrom,
Wei Xu,
Joanne M. Stempak,
A. Hillary Steinhart,
Robin S. McLeod,
Gordon R. Greenberg,
Zane Cohen,
Mark S. Silverberg
et al.
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507-512.e1
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Efficacy of Topical 5-Aminosalicylates in Preventing Relapse of Quiescent Ulcerative Colitis: A Meta-analysis
14 November 2011
Background & Aims: Topical 5-aminosalicylates (5-ASAs) such as mesalamine are effective in inducing remission in patients with mild to moderately active ulcerative colitis (UC). However, there has...
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Alexander C. Ford,
Khurram J. Khan,
William J. Sandborn,
Stephen B. Hanauer,
Paul Moayyedi
et al.
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513-519
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| Original Articles—Liver, Pancreas, and Biliary Tract |
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Telbivudine Prevents Vertical Transmission From HBeAg-Positive Women With Chronic Hepatitis B
16 February 2012
Background & Aims: Telbivudine reduces hepatitis B virus (HBV) DNA and normalizes levels of alanine aminotransferase (ALT) in patients with chronic hepatitis B (CHB). We investigated its use in pr...
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Calvin Q. Pan,
Guo–Rong Han,
Hong–Xiu Jiang,
Wei Zhao,
Min–Kai Cao,
Cui–Min Wang,
Xin Yue,
Gen–Ju Wang
et al.
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520-526
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Incidence and Determinants of Spontaneous Seroclearance of Hepatitis B e Antigen and DNA in Patients With Chronic Hepatitis B
19 December 2011
Background & Aims: The spontaneous seroclearance of hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA are important markers of progression of chronic HBV infection. We performed a long...
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Hwai–I Yang,
Hsiu–Lian Hung,
Mei–Hsuan Lee,
Jessica Liu,
Chin–Lan Jen,
Jun Su,
Li–Yu Wang,
Sheng–Nan Lu,
San–Lin You,
Uchenna H. Iloeje,
Chien–Jen Chen,
Risk Evaluation of Viral Load Elevation and Associated Liver Disease/Cancer–HBV (REVEAL-HBV) Study Group
et al.
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527-534.e2
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Safety of Cardiac Surgery for Patients With Cirrhosis and Child–Pugh Scores Less Than 8
29 December 2011
Background & Aims: Advanced liver disease is a significant risk factor for perioperative complications after cardiac surgery. However, no published studies have adjusted the observed outcomes for ...
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Carole Macaron,
Ibrahim A. Hanouneh,
Amitabh Suman,
Rocio Lopez,
Douglas Johnston,
William W. Carey
et al.
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535-539
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Progressive Primary Sclerosing Cholangitis Requiring Liver Transplantation Is Associated With Reduced Need for Colectomy in Patients With Ulcerative Colitis
16 January 2012
Background & aims: We investigated the association between the severity of primary sclerosing cholangitis (PSC) and clinical outcomes of patients with ulcerative colitis (UC) on the basis of need ...
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Udayakumar Navaneethan,
Preethi G.K. Venkatesh,
Saurabh Mukewar,
Bret A. Lashner,
Feza H. Remzi,
Arthur J. McCullough,
Ravi P. Kiran,
Bo Shen,
John J. Fung
et al.
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540-546
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Medical Care Costs and Survival Associated With Hepatocellular Carcinoma Among the Elderly
30 December 2011
Background & Aims: We assessed the burden of hepatocellular carcinoma (HCC), in terms of mortality and medical care costs, based on analysis of the Surveillance, Epidemiology and End Results (SEER...
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Leigh Ann White,
Joseph Menzin,
Jonathan R. Korn,
Mark Friedman,
Kathy Lang,
Saurabh Ray
et al.
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547-554
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The Clinical Relevance of the Increasing Incidence of Intraductal Papillary Mucinous Neoplasm
29 December 2011
Background & Aims: The incidence of intraductal papillary mucinous neoplasm (IPMN) is believed to be increasing; we investigated whether this is the result of increasing burden of disease or more ...
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David A. Klibansky,
Kaye M. Reid–Lombardo,
Stuart R. Gordon,
Timothy B. Gardner
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555-558
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| Brief Communication |
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Characteristics of Ascites in Patients With Pregnancy-Specific Liver Diseases
16 December 2011
Background & Aims: The characteristics of ascites in patients with pregnancy-specific liver disease (PsLD), which comprise acute fatty liver of pregnancy, hemolysis, increased levels of liver enzy...
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Harshad Devarbhavi,
Prasanna Rao,
Mallikarjun Patil,
Channagiri Krishnamurthy Adarsh
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559-562
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| Letters to the Editor |
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Immunoglobulin E Level and Its Significance in Patients With Primary Sclerosing Cholangitis
30 January 2012
We read with great interest the article by Hirano et al. The authors analyzed data from 44 patients with primary sclerosing cholangitis (PSC) with serum levels of immunoglobulin (Ig)E and found that h...
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Udayakumar Navaneethan,
Preethi G.K. Venkatesh,
Ravi P. Kiran
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563
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Reply
13 February 2012
We thank Nevaneethan et al for their interest in our study and giving us an opportunity to clarify some specific issues regarding ethnic differences in primary sclerosing cholangitis (PSC).
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Kenji Hirano,
Suguru Mizuno,
Kazuhiko Koike
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563-564
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Gastric Acid Suppression and Clostridium difficile Infection: Is There a Causal Connection?
30 January 2012
We read the article by Deshpande et al with great interest. The authors performed a meta-analysis to evaluate the association between proton pump inhibitor (PPI) therapy and the risk of Clostridium di...
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Sahil Khanna,
Darrell S. Pardi
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564
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Reply
13 February 2012
We recognize the concerns raised by Drs Khanna and Pardi in their letter. Regarding the omission of studies from our meta-analysis, the 2 specific papers discussed in their letter are indeed important...
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Abhishek Deshpande,
Vinay Pasupuleti,
Adrian V. Hernandez,
Chaitanya Pant,
Thomas J. Sferra
et al.
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564
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Cover
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OFC
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| Frontmatter |
| Images of the Month |
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Diffuse Hepatic Calcification Following Ischemic Insult in the Setting of Impaired Renal Function
02 November 2011
A 25-year-old man who had undergone liver transplantation 21 years earlier for fulminant hepatitis was admitted to the hospital for elective kidney transplantation for renal failure secondary to calci...
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Ali Raza,
Kashif Ahmed,
Richard P. Rood
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A24
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Liver Invasion of the Duodenum Due to Hepatocellular Carcinoma
10 January 2012
A 68-year-old man with hepatocellular carcinoma (HCC) presented with upper-gastrointestinal bleeding for the fifth time in 7 months and new-onset severe nausea and vomiting. Over the past year, the pa...
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Bryan G. Sauer,
Simone M. Dustin,
Stephen H. Caldwell
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A25
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Kayexalate-Induced Esophageal Ulcer in a Patient With Gastroparesis
26 December 2011
A 53-year-old man presented with an episode of coffee-ground emesis. He had undergone bilateral lung transplantation for idiopathic pulmonary fibrosis 1 month before admission. On presentation, his vi...
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Emmanuel C. Gorospe,
Jason T. Lewis,
David H. Bruining
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A28
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Isolated Jejunal Varices: A Cause of Occult Gastrointestinal Hemorrhage in a Cirrhotic Patient With Mild Portal Hypertension
30 January 2012
A 60-year-old woman with hepatitis C cirrhosis and a history of lymphoma was admitted to our medical center because of recurrent melena. Although hemodynamically stable, she required frequent blood tr...
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Noam Shussman,
Gadi Lalazar,
Allan I. Bloom
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A32
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Editorial Board
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A4
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Contents
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A11-A14
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Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute br...
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A17-A18
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Copyright Assignment, Authorship Responsibility, NIH Funding, Financial Disclosure, Institutional Review Board/Animal Care Committee Approval, and Sponsorship
In consideration of the American Gastroenterological Association (AGA) Institute (the “AGA Institute”) taking action to review and credit the below-identified submission (the “Manuscript”), and for ot...
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A22
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