Clinical Gastroenterology and Hepatology
Volume 7, Issue 11 , Pages 1151-1154, November 2009

Chronic Diarrhea Due to Excessive Bile Acid Synthesis and Not Defective Ileal Transport: A New Syndrome of Defective Fibroblast Growth Factor 19 Release

  • Alan F. Hofmann, MD

      Affiliations

    • Department of Medicine, University of California, San Diego, California
    • ,
  • David J. Mangelsdorf, PhD

      Affiliations

    • Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, Texas
    • Howard Hughes Medical Institute, University of Texas, Southwestern Medical Center, Dallas, Texas
    • ,
  • Steven A. Kliewer, PhD

      Affiliations

    • Department of Pharmacology, University of Texas, Southwestern Medical Center, Dallas, Texas
    • Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas

published online 10 August 2009.

Elsewhere in this issue Julian Walters and his colleagues report a major advance in our understanding of the pathogenesis of chronic diarrhea associated with idiopathic bile acid malabsorption.1 The story is a fascinating one and unites longstanding and very recent discoveries in physiology, biochemistry, and molecular biology.

 

 Conflicts of interest The authors disclose the following: All of the authors have served as ad hoc consultants to Daiichi Sankyo Inc, who market colesevelam for the treatment of type 2 diabetes in the United States.

 Funding This work was supported by National Institutes of Health grant DK067158 and the Welch Foundation (D.J.M. and S.A.K.) and the Howard Hughes Medical Institute (D.J.M.).

PII: S1542-3565(09)00745-9

doi:10.1016/j.cgh.2009.07.026

Clinical Gastroenterology and Hepatology
Volume 7, Issue 11 , Pages 1151-1154, November 2009