Clinical Gastroenterology and Hepatology
Volume 7, Issue 8 , Pages 874-881, August 2009

Risk of Lymphoma Associated With Combination Anti–Tumor Necrosis Factor and Immunomodulator Therapy for the Treatment of Crohn's Disease: A Meta-Analysis

  • Corey A. Siegel

      Affiliations

    • Dartmouth-Hitchcock IBD Center and Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
    • Dartmouth Institute for Health Policy and Clinical Practice, Hanover, New Hampshire
    • Corresponding Author InformationReprint requests Address requests for reprints to: Corey A. Siegel, MD, Section of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756. fax: (603) 650-5225
  • ,
  • Sadie M. Marden

      Affiliations

    • Dartmouth Institute for Health Policy and Clinical Practice, Hanover, New Hampshire
  • ,
  • Sarah M. Persing

      Affiliations

    • Dartmouth Institute for Health Policy and Clinical Practice, Hanover, New Hampshire
  • ,
  • Robin J. Larson

      Affiliations

    • Dartmouth Institute for Health Policy and Clinical Practice, Hanover, New Hampshire
  • ,
  • Bruce E. Sands

      Affiliations

    • MGH Crohn's and Colitis Center and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts

published online 27 January 2009.

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  •  Conflicts of interest The authors disclose the following: Dr Siegel has served as a consultant or on a scientific advisory board for Abbott, Elan, and UCB; has received honoraria for speaking from Abbott, P&G, and UCB; and has received grant support from P&G. Dr Sands has served as a consultant or on a scientific advisory board for Abbott, Biogen/IDEC, Bristol-Myers Squibb, Centocor, Elan, Millenium Pharmaceuticals, Novartis Pharmaceuticals, Otsuka America Pharmaceuticals Inc, and UCB; has received honoraria for speaking from Abbott, Schering-Plough, and UCB; and has received grant support from Abbott, Bristol-Myers Squibb, Centocor, Elan, Millenium Pharmaceutical, Novartis Pharmaceuticals and Otsuka America Pharmaceutical Inc. The remaining authors disclose no conflicts.

     Funding Dr Siegel is supported by a CCFA career development award and by grant number K23DK078678 from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and dose not necessarily represent the official views of the National Institute of Diabetes And Digestive and Kidney Diseases or the National Institute of Health.

    PII: S1542-3565(09)00052-4

    doi:10.1016/j.cgh.2009.01.004

    Clinical Gastroenterology and Hepatology
    Volume 7, Issue 8 , Pages 874-881, August 2009