Clinical Gastroenterology and Hepatology
Volume 6, Issue 12 , Pages 1396-1402 , December 2008

Effect of Bariatric Surgery on Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

  • Rajasekhara R. Mummadi

      Affiliations

    • Internal Medicine, University of Texas Medical Branch, Galveston, Texas
  • ,
  • Krishna S. Kasturi

      Affiliations

    • Internal Medicine, University of Texas Medical Branch, Galveston, Texas
  • ,
  • Swapna Chennareddygari

      Affiliations

    • Internal Medicine, University of Texas Medical Branch, Galveston, Texas
  • ,
  • Gagan K. Sood

      Affiliations

    • Gastroenterology and Hepatology, University of Texas Medical Branch, Galveston, Texas
    • Corresponding Author InformationAddress requests for reprints to: Gagan K. Sood, MD, Gastroenterology and Hepatology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555. fax: (409) 772-4789

References 

  1. Centers for Disease Control and Prevention. National Health and Nutrition Examination Survey. NAHNES 2004. http://www.cdc.gov/nchs/about/major/nhanes/datalink.htmAccessed July 2007
  2. Liou I, Kowdley KV. Natural history of nonalcoholic steatohepatitis. J Clin Gastroenterol. 2006;40(Suppl 1):S11–S16
  3. Clark JM, Alkhuraishi AR, Solga SF, et al. Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease. Obes Res. 2005;13:1180–1186
  4. Barker KB, Palekar NA, Bowers SP, et al. Non-alcoholic steatohepatitis: effect of Roux-en-Y gastric bypass surgery. Am J Gastroenterol. 2006;101:368–373
  5. Angulo P. NAFLD, obesity, and bariatric surgery. Gastroenterology. 2006;130:1848–1852
  6. Schreuder TC, Verwer BJ, van Nieuwkerk CM, et al. Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment. World J Gastroenterol. 2008;14:2474–2486
  7. Sachdev MS, Riely CA, Madan AK. Nonalcoholic fatty liver disease of obesity. Obes Surg. 2006;16:1412–1419
  8. Kowdley KV, Caldwell S. Nonalcoholic steatohepatitis: a twenty-first century epidemic?. J Clin Gastroenterol. 2006;40(Suppl 1):S2–S4
  9. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–1737
  10. Vyberg M, Ravn V, Andersen B. Pattern of progression in liver injury following jejunoileal bypass for morbid obesity. Liver. 1987;7:271–276
  11. Luyckx FH, Desaive C, Thiry A, et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord. 1998;22:222–226
  12. Csendes A, Smok G, Burgos AM. Histological findings in the liver before and after gastric bypass. Obes Surg. 2006;16:607–611
  13. de A, Rocha PR, Sanches MD, et al. Roux-en-Y gastric bypass improves the nonalcoholic steatohepatitis (NASH) of morbid obesity. Obes Surg. 2006;16:270–278
  14. Dixon JB, Bhathal PS, Hughes NR, et al. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology. 2004;39:1647–1654
  15. Liu X, Lazenby AJ, Clements RH, et al. Resolution of nonalcoholic steatohepatitis after gastric bypass surgery. Obes Surg. 2007;17:486–492
  16. Furuya CK, de Oliveira CP, de Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol. 2007;22:510–514
  17. Jaskiewicz K, Raczynska S, Rzepko R, et al. Nonalcoholic fatty liver disease treated by gastroplasty. Dig Dis Sci. 2006;51:21–26
  18. Mattar SG, Velcu LM, Rabinovitz M, et al. Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann Surg. 2005;242:610–617
  19. Mathurin P, Gonzalez F, Kerdraon O, et al. The evolution of severe steatosis after bariatric surgery is related to insulin resistance. Gastroenterology. 2006;130:1617–1624
  20. Mottin CC, Moretto M, Padoin AV, et al. Histological behavior of hepatic steatosis in morbidly obese patients after weight loss induced by bariatric surgery. Obes Surg. 2005;15:788–793
  21. Stratopoulos C, Papakonstantinou A, Terzis I, et al. Changes in liver histology accompanying massive weight loss after gastroplasty for morbid obesity. Obes Surg. 2005;15:1154–1160
  22. Kral JG, Thung SN, Biron S, et al. Effects of surgical treatment of the metabolic syndrome on liver fibrosis and cirrhosis. Surgery. 2004;135:48–58
  23. Silverman EM, Sapala JA, Appelman HD. Regression of hepatic steatosis in morbidly obese persons after gastric bypass. Am J Clin Pathol. 1995;104:23–31
  24. Padoin AV, Mottin CC, Moretto M, et al. A comparison of wedge and needle hepatic biopsy in open bariatric surgery. Obes Surg. 2006;16:178–182
  25. Brunt EM, Janney CG, Di Bisceglie AM, et al. Nonalcoholic steatopatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999;94:2467–2474
  26. Abdelmalek MF, Diehl AM. Nonalcoholic fatty liver disease as a complication of insulin resistance. Med Clin North Am. 2007;91:1125–1149
  27. Sjostrom L, Narbro K, Sjostrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741–752
  28. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753–761

 The authors disclose no conflicts.

PII: S1542-3565(08)00831-8

doi: 10.1016/j.cgh.2008.08.012

Clinical Gastroenterology and Hepatology
Volume 6, Issue 12 , Pages 1396-1402 , December 2008